From CAS (Chemical Abstracts Services) regarding SciFinder (Web and Client versions) substructure searching:
CAS confirms that there is a functional problem with some substructure queries with R-groups containing one or more of the chalcogens (e.g. oxygen, sulfur, selenium, tellurium) or nitrogen in conjunction with shortcut symbols that represent chemical entities that cannot be substituted further (e.g. Me, Et). The query must also contain a chalcogen, or nitrogen somewhere else in the structure with a very specific positional relationship to the R-group. See the following link
for a visual representation:
http://www.cas.org/support/scifi/rgroup.html
SciFinder functionality is being immediately modified to correct this situation. We suggest that you refrain from R-group searches of this type until we confirm we have addressed this, so that our correction can be implemented and fully tested.
Please note that this functional problem is restricted to SciFinder substructure searches (client and web) and does not affect SciFinder reaction searches or any STN searches.
We regret any inconvenience to you and are appreciative that this was brought to our attention.
Jim Corning
jcorning@cas.org
614-447-3600 ext 2082
1 comment:
Sent to the CHMINF list on April 9/09:
CAS is pleased to announce that a recent functional problem related to some substructure searching with R-groups has been corrected in SciFinder. We would like to thank Dr. Engelbert Zass for identifying the error and assisting CAS to correct the problem. We regret any inconvenience that this may have caused.
Crystal Poole Bradley
CAS
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